A smart upconversion-based mesoporous silica nanotheranostic system for synergetic chemo-/radio-/photodynamic therapy and simultaneous MR/UCL imaging

被引：340

作者：

Fan, Wenpei ^{[1
]}

Shen, Bo ^{[2
]}

Bu, Wenbo ^{[1
]}

Chen, Feng ^{[1
]}

He, Qianjun ^{[1
]}

Zhao, Kuaile ^{[3
]}

Zhang, Shengjian ^{[3
]}

Zhou, Liangping ^{[3
]}

Peng, Weijun ^{[3
]}

Xiao, Qingfeng ^{[1
]}

Ni, Dalong ^{[1
]}

Liu, Jianan ^{[1
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Fudan Univ, Inst Radiat Med, Shanghai, Peoples R China

[3] Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai, Peoples R China

来源：

BIOMATERIALS | 2014年 / 35卷 / 32期

基金：

中国国家自然科学基金;

关键词：

Upconversion nanoparticles; Mesoporous silica; Nanotheranostics; Synergetic tri-modal therapy; Bimodal imaging; VIVO PHOTODYNAMIC THERAPY; SHELL NANOPARTICLES; NANOPROBES; DOCETAXEL; DELIVERY; AGENT; BIODISTRIBUTION; RADIOTHERAPY; TOXICITY; CT;

D O I：

10.1016/j.biomaterials.2014.07.024

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may provide a more advanced way for the efficient theranostics of cancer. In this study, sub-80 nm rattle-structured multifunctional Gd-UCNPs core/mesoporous silica shell nanotheranostics (UCMSNs) were successfully constructed for the co-delivery of a radio-/photo-sensitizer hematoporphyrin (HP) and a radiosensitizer/ chemodrug docetaxel (Dtxl). Upon NIR excitation and X-ray irradiation, the complete tumor elimination has been achieved by the synergetic chemo-/radio-/photodynamic tri-modal therapy under the assistance of simultaneous magnetic/upconversion luminescent (MR/UCL) bimodal imaging. To the best of our knowledge, this study is the first example of achieving tri-modal synergetic therapy in one single nanotheranostic system, and we anticipate that it may serve as a particularly useful platform for the clinical diagnosis and efficient treatment of cancer from bench to beside. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：8992 / 9002

页数：11

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