Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High-Intensity Focused Ultrasound Cancer Surgery

被引：175

作者：

Chen, Yu ^{[1
]}

Chen, Hangrong ^{[1
]}

Sun, Yang ^{[2
]}

Zheng, Yuanyi ^{[2
]}

Zeng, Deping ^{[3
,4
]}

Li, Faqi ^{[3
,4
]}

Zhang, Shengjian ^{[5
,6
]}

Wang, Xia ^{[1
]}

Zhang, Kun ^{[1
]}

Ma, Ming ^{[1
]}

He, Qianjun ^{[1
]}

Zhang, Linlin ^{[1
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China

[3] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Engn Med Cofounded Chong, Chongqing 400016, Peoples R China

[4] Chongqing Med Univ, Coll Biomed Engn, Minist Sci & Technol, Chongqing Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China

[5] Fudan Univ, Shanghai Med Coll, Dept Radiol, Inst Oncol,Canc Hosp, Shanghai 200032, Peoples R China

[6] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 52期

关键词：

high-intensity focused ultrasound; imaging agents; magnetic resonance imaging; mesoporous materials; nanotechnology; MAGNETIC-RESONANCE; CONTRAST AGENTS; BREAST-CANCER; NANOPARTICLES; DELIVERY; PLATFORM; THERAPY; FUTURE;

D O I：

10.1002/anie.201106180

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bloodless surgical knife: Nano-biotechnology has been introduced into imaging-guided high-intensity focused ultrasound (HIFU) cancer surgery by adopting engineered multifunctional manganese-based mesoporous composite nanocapsules as the contrast agents for T 1-weighted magnetic resonance imaging (MRI) and simultaneously as synergistic agents for MRI-guided HIFU cancer surgery. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12505 / 12509

页数：5

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