A Uniform Sub-50 nm-Sized Magnetic/Upconversion Fluorescent Bimodal Imaging Agent Capable of Generating Singlet Oxygen by Using a 980 nm Laser

被引：193

作者：

Chen, Feng ^{[1
]}

Zhang, Shengjian ^{[2
]}

Bu, Wenbo ^{[1
]}

Chen, Yu ^{[1
]}

Xiao, Qingfeng ^{[1
]}

Liu, Jianan ^{[1
]}

Xing, Huaiyong ^{[1
]}

Zhou, Liangping ^{[2
]}

Peng, Weijun ^{[2
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Grp Mesoporous & Low Dimens Nanomat, Shanghai 200050, Peoples R China

[2] Fudan Univ, Shanghai Canc Ctr, Shanghai Med Coll, Dept Radiol,Dept Oncol, Shanghai 200433, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 23期

基金：

中国国家自然科学基金;

关键词：

imaging agents; methylene blue; nanoparticles; photodynamic therapy; singlet oxygen; UP-CONVERSION NANOPARTICLES; PHOTODYNAMIC THERAPY; METHYLENE-BLUE; UPCONVERTING NANOPARTICLES; MAGNETIC-RESONANCE; QUANTUM DOTS; NANOCRYSTALS; CANCER; LUMINESCENCE; PHOTOSENSITIZERS;

D O I：

10.1002/chem.201103611

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Upconverting nanoparticles (UCNPs) with fascinating properties hold great potential as nanotransducers for solving the problems that traditional photodynamic therapy (PDT) has been facing. In this report, by using well-selected bifunctional gadolinium (Gd)-ion-doped UCNPs and water-soluble methylene blue (MB) combined with the water-in-oil reverse microemulsion technique, we have succeeded in developing a new kind of UCNP/MB-based PDT drug, NaYF4:Er/Yb/Gd@SiO2(MB), with a particle diameter less than 50 nm. Great efforts have been made to investigate the drug-formation mechanism and provide detailed physical and photochemical characterizations and the potential structure optimization of the as-designed PDT drug. We envision that such a PDT drug will become a potential theranostic nanomedicine for future near-infrared laser-triggered photodynamic therapy and simultaneous magnetic/optical bimodal imaging.

引用

页码：7082 / 7090

页数：9

共 53 条

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