A "Neck-Formation" Strategy for an Antiquenching Magnetic/Upconversion Fluorescent Bimodal Cancer Probe

被引：54

作者：

Chen, Feng ^{[1
]}

Zhang, Shengjian ^{[2
]}

Bu, Wenbo ^{[1
]}

Liu, Xiaohang ^{[2
]}

Chen, Yu ^{[1
]}

He, Qianjun ^{[1
]}

Zhu, Min ^{[1
]}

Zhang, Lingxia ^{[1
]}

Zhou, Liangping ^{[2
]}

Peng, Weijun ^{[2
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China

[2] Fudan Univ, Dept Radiol, Shanghai Canc Hosp, Shanghai 200032, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 37期

基金：

中国国家自然科学基金;

关键词：

antitumor agents; fluorescence; imaging agents; magnetic resonance imaging; neck formation; UP-CONVERSION FLUORESCENT; PERFORMANCE MAGNETIC-RESONANCE; IRON-OXIDE NANOPARTICLES; QUANTUM DOTS; SILICA NANOPARTICLES; DRUG-DELIVERY; IN-VIVO; NANOCOMPOSITE SPHERES; CONTRAST AGENTS; IMAGING PROBE;

D O I：

10.1002/chem.201000525

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Up to the neck! Bio-safe upconversion fluorescent nanocrystals (NaYF 4:ErYb) and biocompatible superparamagnetic iron oxide nanocrystals (SPION) were effectively combined by means of a general neck- formation" strategy forming a size-controlled Cd2+- and Gd 3+-free silica-shielded magnetic upconversion fluorescent oligomer (SMUFO) bimodal cancer probe that offers high resistance to photoquenching as well as a synergistic T2-weighted magnetic resonance enhanced effect (see graphic). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA."

引用

页码：11254 / 11260

页数：7

共 75 条

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