Multistep Continuous-Flow Microsynthesis of Magnetic and Fluorescent γ-Fe2O3@SiO2 Core/Shell Nanoparticles

被引:94
作者
Abou-Hassan, Ali [1 ]
Bazzi, Rana [1 ]
Cabuil, Valerie [1 ]
机构
[1] Univ Paris 06, Lab PECSA, UMR 7195, Equipe Colloides Inorgan, F-75252 Paris 05, France
关键词
core-shell structures; lab-on-a-chip; microreactors; multistep synthesis; nanoparticles; MICROFLUIDIC SYNTHESIS; QUANTUM DOTS; PARTICLES;
D O I
10.1002/anie.200902181
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Coupled microreactors allow fast, continuous, multistep synthesis of the title compound. Thus, grafting with APTES is carried out in microreactor I, mixing with sol-gel TEOS and APTES labeled with Rhodamine B isothiocyanate (RITC) in II, and coating in III. This technique opens the way to developing a lab-on-a-chip platform for nanoparticle synthesis. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.
引用
收藏
页码:7180 / 7183
页数:4
相关论文
共 43 条
[1]   Synthesis of iron oxide nanoparticles in a microfluidic device: preliminary results in a coaxial flow millichannel [J].
Abou Hassan, Ali ;
Sandre, Olivier ;
Cabuil, Valerie ;
Tabeling, Patrick .
CHEMICAL COMMUNICATIONS, 2008, (15) :1783-1785
[2]   Synthesis of Goethite by Separation of the Nucleation and Growth Processes of Ferrihydrite Nanoparticles Using Microfluidics [J].
Abou-Hassan, Ali ;
Sandre, Olivier ;
Neveu, Sophie ;
Cabuil, Valerie .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (13) :2342-2345
[3]   Manipulation of the magnetic properties of magnetite-silica nanocomposite materials by controlled Stober synthesis [J].
Barnakov, YA ;
Yu, MH ;
Rosenzweig, Z .
LANGMUIR, 2005, 21 (16) :7524-7527
[4]   A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly [J].
Baxendale, Ian R. ;
Deeley, Jon ;
Griffiths-Jones, Charlotte M. ;
Ley, Steven V. ;
Saaby, Steen ;
Tranmer, Geoffrey K. .
CHEMICAL COMMUNICATIONS, 2006, (24) :2566-2568
[5]   Enantioselective catalysis and analysis on a chip [J].
Belder, D ;
Ludwig, M ;
Wang, LW ;
Reetz, MT .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (15) :2463-2466
[6]  
BELDER D, 2006, ANGEW CHEM, V118, P2523
[7]  
Cabuil, 2009, ANGEW CHEM, V121, P2378, DOI [10.1002/ange.200805933, DOI 10.1002/ANGE.200805933]
[8]   Synthesis and post-processing of nanomaterials using microreaction technology [J].
Chang, Chih-Hung ;
Paul, Brian K. ;
Remcho, Vincent T. ;
Atre, Sundar ;
Hutchison, James E. .
JOURNAL OF NANOPARTICLE RESEARCH, 2008, 10 (06) :965-980
[9]   Monodisperse magnetizable composite silica spheres with tunable dipolar interactions [J].
Claesson, EM ;
Philipse, AP .
LANGMUIR, 2005, 21 (21) :9412-9419
[10]   Accelerated synthesis of titanium oxide nanostructures using microfluidic chips [J].
Cottam, Ben F. ;
Krishnadasan, Siva ;
deMello, Andrew J. ;
deMello, John C. ;
Shaffer, Milo S. P. .
LAB ON A CHIP, 2007, 7 (02) :167-169