A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly

被引：275

作者：

Baxendale, Ian R. ^{[1
]}

Deeley, Jon ^{[1
]}

Griffiths-Jones, Charlotte M. ^{[1
]}

Ley, Steven V. ^{[1
]}

Saaby, Steen ^{[1
]}

Tranmer, Geoffrey K. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 24期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1039/b600382f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A flow process for the multi-step synthesis of the alkaloid natural product (+/-)-oxomaritidine is described, mediated through the use of microfluidic pumping systems that progress material through various packed columns containing immobilized reagents, catalysts, scavengers or catch and release agents; our route involves the combination of seven separate synthetic steps linked into one continuous sequence utilizing flow chemistry.

引用

页码：2566 / 2568

页数：3

共 27 条

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