Mixed Periodic Mesoporous Organosilica Nanoparticles and Core-Shell Systems, Application to in Vitro Two-Photon Imaging, Therapy, and Drug Delivery

被引：79

作者：

Croissant, Jonas ^{[1
]}

Salles, Damien ^{[1
]}

Maynadier, Marie ^{[6
]}

Mongin, Olivier ^{[2
]}

Hugues, Vincent ^{[3
]}

Banchard-Desce, Mireille ^{[3
]}

Cattoen, Xavier ^{[1
,4
,5
]}

Man, Michel Wong Chi ^{[1
]}

Gallud, Audrey ^{[6
]}

Garcia, Marcel ^{[6
]}

Gary-Bobo, Magali ^{[6
]}

Raehm, Laurence ^{[1
]}

Durand, Jean-Olivier ^{[1
]}

机构：

[1] UMR 5253 CNRS UM2 ENSCM UM1, Inst Charles Gerhardt Montpellier, F-34095 Montpellier 05, France

[2] Univ Rennes 1, CNRS UMR 6226, Inst Sci Chim Rennes, F-35042 Rennes, France

[3] Univ Bordeaux, UMR CNRS 5255, Inst Sci Mol, F-33405 Talence, France

[4] CNRS, Inst NEEL, F-38042 Grenoble, France

[5] Univ Grenoble Alpes, F-38042 Grenoble, France

[6] Univ Montpellier, Fac Pharm, Inst Biomol Max Mousseron, UMR 5247,CNRS,UM1,UM2, F-34093 Montpellier 05, France

来源：

CHEMISTRY OF MATERIALS | 2014年 / 26卷 / 24期

关键词：

NANOSPHERES; NANORODS;

D O I：

10.1021/cm5040276

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

In this work, we describe the synthesis of new Mixed Periodic Mesoporous Organosilica Nanoparticles (MPMO NPs), combining the co-condensation of a tetra-trialkoxysilylated two-photon photosensitizer with bis-(triethoxysilyl)phenylene or ethylene. Novel gold core-MPMO shell systems are also described. The MPMO NPs are analyzed and characterized by multiple techniques, and are very efficient for anti-cancer drug delivery combined with two-photon therapy in MCF-7 breast cancer cells, leading down to 76% cancer cell death. MPMO NPs are thus very promising for nanomedicine applications.

引用

页码：7214 / 7220

页数：7

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