Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine

被引：384

作者：

Chen, Yu ^{[1
,2
,3
]}

Meng, Qingshuo ^{[4
]}

Wu, Meiying ^{[1
]}

Wang, Shige ^{[1
]}

Xu, Pengfei ^{[4
]}

Chen, Hangrong ^{[1
]}

Li, Yaping ^{[4
]}

Zhang, Lingxia ^{[1
]}

Wang, Lianzhou ^{[2
,3
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Univ Queensland, Sch Chem Engn, Nanomat Ctr, Brisbane, Qld 4072, Australia

[3] Univ Queensland, Australia Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[4] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 46期

基金：

澳大利亚研究理事会;

关键词：

SILICA NANOPARTICLES; DRUG-DELIVERY; TOPOLOGICAL TRANSFORMATION; GOLD NANOSHELLS; SHELL; THERAPY; CORE; SIZE; BIODISTRIBUTION; NANOSTRUCTURES;

D O I：

10.1021/ja508721y

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Chemical construction of molecularly organic inorganic hybrid hollow mesoporous organosilica nano-particles (HMONs) with silsesquioxane framework is expected to substantially improve their therapeutic performance and enhance the biological effects beneficial for biomedicine. In this work, we report on a simple, controllable, and versatile chemical homology principle to synthesize multiple-hybridized HMONs with varied functional organic groups homogeneously incorporated into the framework (up to quintuple hybridizations). As a paradigm, the hybridization of physiologically active thioether groups with triple distinctive disulfide bonds can endow HMONs with unique intrinsic reducing/acidic- and external high intensity focused ultrasound (HIFU)-responsive drug-releasing performances, improved biological effects (e.g., lowered hemolytic effect and improved histocompatibility), and enhanced ultrasonography behavior. The doxorubicin-loaded HMONs with concurrent thioether and phenylene hybridization exhibit drastically enhanced therapeutic efficiency against cancer growth and metastasis, as demonstrated both in vitro and in vivo.

引用

页码：16326 / 16334

页数：9

共 45 条

[1]

Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine [J].