Biodegradable Ethylene-Bis(Propyl)Disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery

被引：277

作者：

Croissant, Jonas ^{[1
]}

Cattoen, Xavier ^{[1
]}

Man, Michel Wong Chi ^{[1
]}

Gallud, Audrey ^{[1
]}

Raehm, Laurence ^{[1
]}

Trens, Philippe ^{[1
]}

Maynadier, Marie ^{[1
]}

Durand, Jean-Olivier ^{[1
]}

机构：

[1] UMR 5253 CNRS UM2 ENSCM UM1cc 1701, Inst Charles Gerhardt Montpellier, F-34095 Montpellier 05, France

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 35期

关键词：

SILICA NANOPARTICLES; ORGANIC GROUPS; ADSORPTION; BENZENE; SHELL; TRANSFORMATION; PERFORMANCE; RELEASE;

D O I：

10.1002/adma.201401931

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4-bis(triethoxysilyl)ethylene and bis(3-ethoxysilylpropyl)disulfide. The nanosystems present the long-range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.

引用

页码：6174 / +

页数：8

共 36 条

[1]

Periodic mesoporous organosilicas with organic groups inside the channel walls [J].

Asefa, T ;

MacLachlan, MJ ;

Coombs, N ;

Ozin, GA .

NATURE, 1999, 402 (6764) :867-871

[2]

A Vanadyl Complex Grafted to Periodic Mesoporous Organosilica: A Green Catalyst for Selective Hydroxylation of Benzene to Phenol [J].

Borah, Parijat ;

Ma, Xing ;

Kim Truc Nguyen ;

Zhao, Yanli .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (31) :7756-7761

[3]

Colloidal HPMO Nanoparticles: Silica-Etching Chemistry Tailoring, Topological Transformation, and Nano-Biomedical Applications [J].

Chen, Yu ;

Xu, Pengfei ;

Chen, Hangrong ;

Li, Yongsheng ;

Bu, Wenbo ;

Shu, Zhu ;

Li, Yaping ;

Zhang, Jiamin ;

Zhang, Lingxia ;

Pan, Limin ;

Cui, Xiangzhi ;

Hua, Zile ;

Wang, Jin ;

Zhang, Linlin ;

Shi, Jianlin .

ADVANCED MATERIALS, 2013, 25 (22) :3100-3105

[4]

Preparation of mesoporous benzene-silica nanoparticles [J].

Cho, Eun-Bum ;

Kim, Dukjoon ;

Jaroniec, Mietek .

MICROPOROUS AND MESOPOROUS MATERIALS, 2009, 120 (03) :252-256

[5]

Periodic mesoporous organosilicas functionalized with a wide variety of amines for CO2 adsorption [J].

De Canck, Els ;

Ascoop, Isabelle ;

Sayari, Abdelhamid ;

Van Der Voort, Pascal .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2013, 15 (24) :9792-9799

[6]

Periodic mesoporous organosilica hollow spheres with tunable wall thickness [J].

Djojoputro, H. ;

Zhou, X. F. ;

Qiao, S. Z. ;

Wang, L. Z. ;

Yu, C. Z. ;

Lu, G. Q. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (19) :6320-6321

[7]

Micelle-templated silicates as a test bed for methods of mesopore size evaluation [J].

Galarneau, A ;

Desplantier, D ;

Dutartre, R ;

Di Renzo, F .

MICROPOROUS AND MESOPOROUS MATERIALS, 1999, 27 (2-3) :297-308

[8]

Clickable Periodic Mesoporous Organosilicas: Synthesis, Click Reactions, and Adsorption of Antibiotics [J].

Gao, Jinsuo ;

Zhang, Xueying ;

Xu, Shutao ;

Tan, Feng ;

Li, Xinyong ;

Zhang, Yaobin ;

Qu, Zhenping ;

Quan, Xie ;

Liu, Jian .

CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (07) :1957-1963

[9]

Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles [J].

Gao, Yu ;

Chen, Yu ;

Ji, Xiufeng ;

He, Xinyu ;

Yin, Qi ;

Zhang, Zhiwen ;

Shi, Jianlin ;

Li, Yaping .

ACS NANO, 2011, 5 (12) :9788-9798

[10]

Bipyridine Periodic Mesoporous Organosilica: A Solid Ligand for the Iridium- Catalyzed Borylation of C-H Bonds [J].

Gruening, Wolfram R. ;

Siddiqi, Georges ;

Safonova, Olga V. ;

Coperet, Christophe .

ADVANCED SYNTHESIS & CATALYSIS, 2014, 356 (04) :673-679

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