Polysilsesquioxane Nanoparticles for Targeted Platin-Based Cancer Chemotherapy by Triggered Release

被引：91

作者：

Della Rocca, Joseph ^{[1
]}

Huxford, Rachel C. ^{[1
]}

Comstock-Duggan, Erica ^{[1
]}

Lin, Wenbin ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Chem, Chapel Hill, NC 27599 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 44期

关键词：

antitumor agents; drug delivery; nanoparticles; oxaliplatin; polysilsesquioxanes; DELIVERY; RECEPTORS; ADENOCARCINOMAS; EXPRESSION; POLYMERS; LIGANDS; AGENTS; CELLS;

D O I：

10.1002/anie.201104510

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Trigger happy: Polysilsesquioxane (PSQ) nanoparticles that contain a Pt IV-based active agent (1; see picture) can be used for the triggered delivery of chemotherapeutics. The cytotoxicity of 1 was superior to that of oxaliplatin against four cancer cell lines in vitro, and targeting further enhanced the cytotoxicity. PEGylated and anisamide-targeted 1 showed drastically superior efficacy to oxaliplatin in inhibiting tumor growth. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：10330 / 10334

页数：5

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