Two-Photon-Triggered Drug Delivery via Fluorescent Nanovalves

被引：107

作者：

Croissant, Jonas ^{[1
]}

Chaix, Arnaud ^{[1
,6
]}

Mongin, Olivier ^{[4
]}

Wang, Miao ^{[1
]}

Clement, Sebastien ^{[1
]}

Raehm, Laurence ^{[1
]}

Durand, Jean-Olivier ^{[1
]}

Hugues, Vincent ^{[3
]}

Blanchard-Desce, Mireille ^{[3
]}

Maynadier, Marie ^{[2
]}

Gallud, Audrey ^{[2
]}

Gary-Bobo, Magali ^{[2
]}

Garcia, Marcel ^{[2
]}

Lu, Jie ^{[5
]}

Tamanoi, Fuyuhiko ^{[5
]}

Ferris, Daniel P. ^{[6
]}

Tarn, Derrick ^{[6
]}

Zink, Jeffrey I. ^{[6
]}

机构：

[1] UM1, UM2, ENSCM, Inst Charles Gerhardt Montpellier,UMR 5253,CNRS, F-34095 Montpellier 05, France

[2] UM 2, Fac Pharm, UM 1, Inst Biomol Max Mousseron,UMR 5247,CNRS, F-34093 Montpellier 05, France

[3] Univ Bordeaux, Inst Sci Mol, CNRS, UMR 5255, F-33405 Talence, France

[4] Univ Rennes 1, Inst Sci Chim Rennes, CNRS, UMR 6226, F-35042 Rennes, France

[5] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

SMALL | 2014年 / 10卷 / 09期

关键词：

two-photon; drug delivery; cancer; nanovalves; mesoporous silica nanoparticles; light; MESOPOROUS SILICA NANOPARTICLES; RELEASE; BIOCOMPATIBILITY;

D O I：

10.1002/smll.201400042

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Mesoporous silica nanoparticles (MSN) are functionalized in the walls with an original fluorophore with a high two-photon absorption cross-section. The pores of the MSN filled with anticancer drug are blocked with a pseudo-rotaxane constituted by an azobenzene stalk and a β-cyclodextrin moiety. After incubation of the nanosystem with MCF-7 breast cancer cells, two-photon irradiation at low power is used to image the cells. At high power, cancer cell killing is observed due to the two-photon-triggered opening of the pores through FRET and the release of the anticancer drug from the MSN. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：1752 / 1755

页数：4

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