Tooth Regeneration: Insights from Tooth Development and Spatial-Temporal Control of Bioactive Drug Release

被引：29

作者：

Huang, Delan ^{[1
,2
]}

Ren, Jianhan ^{[1
,2
]}

Li, Runze ^{[1
,2
]}

Guan, Chenyu ^{[1
,2
]}

Feng, Zhicai ^{[1
,2
]}

Bao, Baicheng ^{[1
,2
]}

Wang, Weicai ^{[1
,2
]}

Zhou, Chen ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Guanghua Sch Stomatol, Hosp Stomatol, Guangzhou, Peoples R China

[2] Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Guangzhou, Peoples R China

来源：

STEM CELL REVIEWS AND REPORTS | 2020年 / 16卷 / 01期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Tooth development; Spatial-temporal control of drug release; Cytokines; Biodegradable materials; Tooth regeneration; MESENCHYMAL STEM-CELLS; GENE-EXPRESSION SYSTEM; SPATIOTEMPORAL CONTROL; SONIC HEDGEHOG; NEURAL CREST; BONE TISSUE; DELIVERY; WNT; MORPHOGENESIS; THERAPY;

D O I：

10.1007/s12015-019-09940-0

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive factors are expressed in a spatial-temporal pattern during tooth development. On the other hand, the technology for spatial-temporal control of drug release has been intensively studied and well developed recently, making control release of these bioactive factors mimicking spatial-temporal pattern more feasible than ever for the purpose of tooth regeneration. This article reviews the research progress on the tooth development and discusses the future of tooth regeneration in the context of spatial-temporal release of developmental factors.

引用

收藏

页码：41 / 55

页数：15

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