Polycomb Group proteins: an evolutionary perspective

被引：144

作者：

Whitcomb, Sarah J. ^{[1
]}

Basu, Amrita ^{[1
]}

Allis, C. David ^{[1
]}

Bernstein, Emily ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Chromatin Biol, New York, NY 10065 USA

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 10期

关键词：

D O I：

10.1016/j.tig.2007.08.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The chromatin-associated Polycomb Group (PcG) proteins were first identified in genetic screens for homeotic transformations in Drosophila melanogaster. In addition to body patterning in metazoans, members of the PcG are now known to regulate epigenetic cellular memory, pluripotency and stem cell self-renewal. Here, we discuss the functional versatility of the PcG family and the evolutionary history of a subset of these proteins including Drosophila E(z), Pc, Psc, dRing and their homologs in plants and animals. We propose that PcG gene expansion and diversification contributed significantly to the complexity of heritable gene repression mechanisms in extant multicellular organisms.

引用

页码：494 / 502

页数：9

共 73 条

[1] cec-1, a soma-specific chromobox-containing gene in C-Elegans [J].

Agostoni, E ;

Albertson, D ;

Wittmann, C ;

Hill, F ;

Tobler, H ;

Muller, F .

DEVELOPMENTAL BIOLOGY, 1996, 178 (02) :316-326

[2]

Akasaka T, 1996, DEVELOPMENT, V122, P1513

[3] The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity [J].

Ben-Saadon, Ronen ;

Zaaroor, Daphna ;

Ziv, Tamar ;

Ciechanover, Aaron .

MOLECULAR CELL, 2006, 24 (05) :701-711

[4] Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin [J].

Bernstein, E ;

Duncan, EM ;

Masui, O ;

Gil, J ;

Heard, E ;

Allis, CD .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (07) :2560-2569

[5]

Birve A, 2001, DEVELOPMENT, V128, P3371

[6] Polycomb complexes repress developmental regulators in murine embryonic stem cells [J].

Boyer, LA ;

Plath, K ;

Zeitlinger, J ;

Brambrink, T ;

Medeiros, LA ;

Lee, TI ;

Levine, SS ;

Wernig, M ;

Tajonar, A ;

Ray, MK ;

Bell, GW ;

Otte, AP ;

Vidal, M ;

Gifford, DK ;

Young, RA ;

Jaenisch, R .

NATURE, 2006, 441 (7091) :349-353

[7] Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions [J].

Bracken, AP ;

Dietrich, N ;

Pasini, D ;

Hansen, KH ;

Helin, K .

GENES & DEVELOPMENT, 2006, 20 (09) :1123-1136

[8] Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b [J].

Buchwald, Gretel ;

van der Stoop, Petra ;

Weichenrieder, Oliver ;

Perrakis, Anastassis ;

van Lohuizen, Maarten ;

Sixma, Titia K. .

EMBO JOURNAL, 2006, 25 (11) :2465-2474

[9] The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3 [J].

Cao, R ;

Zhang, Y .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (02) :155-164

[10] Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing [J].

Cao, R ;

Tsukada, Y ;

Zhang, Y .

MOLECULAR CELL, 2005, 20 (06) :845-854

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