The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3

被引：746

作者：

Cao, R ^{[1
]}

Zhang, Y ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Canc Res Ctr, Dept Biochem & Biophys, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/j.gde.2004.02.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polycomb group (PcG) proteins are important for maintaining the silenced state of homeotic genes. Biochemical and genetic studies in Drosophila and mammalian cells indicate that PcG proteins function in at least two distinct protein complexes: the ESC-E(Z) or EED-EZH2 complex, and the PRC1 complex. Recent work has shown that at least part of the silencing function of the ESC-E(Z) complex is mediated by its intrinsic activity for methylating histone H3 on lysine 27. In addition to being involved in Hox gene silencing, the complex and its associated histone methyltransferase activity are important in other biological processes including X-inactivation, germline development, stem cell pluripotency and cancer metastasis.

引用

页码：155 / 164

页数：10

共 71 条

[1] X-chromosome inactivation: Counting, choice and initiation [J].

Avner, P ;

Heard, E .

NATURE REVIEWS GENETICS, 2001, 2 (01) :59-67

[2] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].

Bannister, AJ ;

Zegerman, P ;

Partridge, JF ;

Miska, EA ;

Thomas, JO ;

Allshire, RC ;

Kouzarides, T .

NATURE, 2001, 410 (6824) :120-124

[3] Histone methylation: Dynamic or static? [J].

Bannister, AJ ;

Schneider, R ;

Kouzarides, T .

CELL, 2002, 109 (07) :801-806

[4] RETRACTED: Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1 (Retracted article. See vol. 521, pg. 110, 2015) [J].

Beisel, C ;

Imhof, A ;

Greene, J ;

Kremmer, E ;

Sauer, F .

NATURE, 2002, 419 (6909) :857-862

[5] Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes [J].

Boggs, BA ;

Cheung, P ;

Heard, E ;

Spector, DL ;

Chinault, AC ;

Allis, CD .

NATURE GENETICS, 2002, 30 (01) :73-76

[6]

Boumil RM, 2001, HUM MOL GENET, V10, P2225

[7] EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer [J].

Adrian P. Bracken ;

Diego Pasini ;

Maria Capra ;

Elena Prosperini ;

Elena Colli ;

Kristian Helin .

The EMBO Journal, 2003, 22 (20) :5323-5335

[8] X-chromosome inactivation:: closing in on proteins that bind XistRNA [J].

Brockdorff, N .

TRENDS IN GENETICS, 2002, 18 (07) :352-358

[9] Role of histone H3 lysine 27 methylation in polycomb-group silencing [J].

Cao, R ;

Wang, LJ ;

Wang, HB ;

Xia, L ;

Erdjument-Bromage, H ;

Tempst, P ;

Jones, RS ;

Zhang, Y .

SCIENCE, 2002, 298 (5595) :1039-1043

[10]

CAPOWSKI EE, 1991, GENETICS, V129, P1061

← 1 2 3 4 5 6 7 8 →