The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3

被引：746

作者：

Cao, R ^{[1
]}

Zhang, Y ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Canc Res Ctr, Dept Biochem & Biophys, Curriculum Genet & Mol Biol, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/j.gde.2004.02.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polycomb group (PcG) proteins are important for maintaining the silenced state of homeotic genes. Biochemical and genetic studies in Drosophila and mammalian cells indicate that PcG proteins function in at least two distinct protein complexes: the ESC-E(Z) or EED-EZH2 complex, and the PRC1 complex. Recent work has shown that at least part of the silencing function of the ESC-E(Z) complex is mediated by its intrinsic activity for methylating histone H3 on lysine 27. In addition to being involved in Hox gene silencing, the complex and its associated histone methyltransferase activity are important in other biological processes including X-inactivation, germline development, stem cell pluripotency and cancer metastasis.

引用

页码：155 / 164

页数：10

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