Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

被引：489

作者：

Su, IH

Basavaraj, A

Krutchinsky, AN

Hobert, O

Ullrich, A

Chait, BT

Tarakhovsky, A

机构：

[1] Rockefeller Univ, Lab Lymphocyte Signaling, New York, NY 10021 USA

[2] Rockefeller Univ, Lab Mass Spectrometry & Gaseous Ion Chem, New York, NY 10021 USA

[3] Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, New York, NY 10032 USA

[4] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 02期

关键词：

D O I：

10.1038/ni876

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polycomb group protein Ezh2 is an essential epigenetic regulator of embryonic development in mice, but its role in the adult organism is unknown. High expression of Ezh2 in developing murine lymphocytes suggests Ezh2 involvement in lymphopoiesis. Using Cre-mediated conditional mutagenesis, we demonstrated a critical role for Ezh2 in early B cell development and rearrangement of the immunoglobulin heavy chain gene (Igh). We also revealed Ezh2 as a key regulator of histone H3 methylation in early B cell progenitors. Our data suggest Ezh2-dependent histone H3 methylation as a novel regulatory mechanism controlling Igh rearrangement during early murine B cell development.

引用

页码：124 / 131

页数：8

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[1] The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors [J].