The eosinophil ribonucleases

被引：72

作者：

Rosenberg, HF ^{[1
]}

机构：

[1] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1998年 / 54卷 / 08期

关键词：

eosinophils; host defence; primates; rodents; evolution;

D O I：

10.1007/s000180050208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The eosinophil ribonucleases, eosinophil-derived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3) are two closely related proteins with intriguing functional and evolutionary properties. While both EDN and ECP maintain the structural and catalytic residues typical of the RNase A superfamily, the role of ribonuclease activity in the physiologic function of these proteins remains unclear. The biochemistry and physiology of EDN, ECP and the recently discovered ribonuclease k6 (RNase 6) will be reviewed in this chapter.

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收藏

页码：795 / 803

页数：9

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