Paracaspase (MALT1), a member of an evolutionarily conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10 in vitro and, because of this association, has been suggested to be involved in the CARMA1-Bcl10 pathway of antigen-induced nuclear factor kappaB (NF-kappaB) activation. We demonstrate that primary T and B lymphocytes from para-caspase-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation. Paracaspase acts downstream of Bcl10 to induce NF-kappaB activation and is required for the normal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and activation of the IkappaB kinase complex.
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页码:1581 / 1584
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[1]
Bertoni Francesco, 2002, Hematol J, V3, P10, DOI 10.1038/sj.thj.6200146
机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Jun, JE
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Wilson, LE
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Wilson, LE
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Vinuesa, CG
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Vinuesa, CG
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Lesage, S
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Lesage, S
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Blery, M
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Blery, M
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Miosge, LA
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Miosge, LA
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Cook, MC
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Cook, MC
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Kucharska, EM
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Kucharska, EM
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Hara, H
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Hara, H
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Penninger, JM
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Penninger, JM
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Domashenz, H
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Domashenz, H
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Hong, NA
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Hong, NA
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Glynne, RJ
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Glynne, RJ
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Nelms, KA
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Nelms, KA
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Goodnow, CC
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Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
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Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, La Jolla, CA 92093 USAUniv Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, La Jolla, CA 92093 USA
Karin, M
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Ben-Neriah, Y
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机构:Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, La Jolla, CA 92093 USA
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Univ Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA
Martin, F
;
Kearney, JF
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Univ Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA
机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Jun, JE
;
Wilson, LE
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Wilson, LE
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Vinuesa, CG
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Vinuesa, CG
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Lesage, S
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h-index: 0
机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Lesage, S
;
Blery, M
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Blery, M
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Miosge, LA
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Miosge, LA
;
Cook, MC
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Cook, MC
;
Kucharska, EM
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Kucharska, EM
;
Hara, H
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Hara, H
;
Penninger, JM
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Penninger, JM
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Domashenz, H
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Domashenz, H
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Hong, NA
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Hong, NA
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Glynne, RJ
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Glynne, RJ
;
Nelms, KA
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机构:Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
Nelms, KA
;
Goodnow, CC
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Australian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, AustraliaAustralian Natl Univ, John Curtin Sch Med Res, Australian Canc Res Fdn, Genet Lab, Canberra, ACT 2601, Australia
机构:
Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, La Jolla, CA 92093 USAUniv Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, La Jolla, CA 92093 USA
Karin, M
;
Ben-Neriah, Y
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机构:Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, La Jolla, CA 92093 USA
机构:
Univ Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA
Martin, F
;
Kearney, JF
论文数: 0引用数: 0
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机构:
Univ Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA