Regulation of NF-κB-dependent lymphocyte activation and development by paracaspase

被引:302
作者
Ruefli-Brasse, AA
French, DM
Dixit, VM
机构
[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA
[2] Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA
关键词
D O I
10.1126/science.1090769
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Paracaspase (MALT1), a member of an evolutionarily conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10 in vitro and, because of this association, has been suggested to be involved in the CARMA1-Bcl10 pathway of antigen-induced nuclear factor kappaB (NF-kappaB) activation. We demonstrate that primary T and B lymphocytes from para-caspase-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation. Paracaspase acts downstream of Bcl10 to induce NF-kappaB activation and is required for the normal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and activation of the IkappaB kinase complex.
引用
收藏
页码:1581 / 1584
页数:4
相关论文
共 18 条
[1]  
Bertoni Francesco, 2002, Hematol J, V3, P10, DOI 10.1038/sj.thj.6200146
[2]   Requirement for CARMA1 in antigen receptor-induced NF-κB activation and lymphocyte proliferation [J].
Egawa, T ;
Albrecht, B ;
Favier, B ;
Sunshine, MJ ;
Mirchandani, K ;
O'Brien, W ;
Thome, M ;
Littman, DR .
CURRENT BIOLOGY, 2003, 13 (14) :1252-1258
[3]   NF-κB and rel proteins:: Evolutionarily conserved mediators of immune responses [J].
Ghosh, S ;
May, MJ ;
Kopp, EB .
ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :225-260
[4]   The MAGUK family protein CARD11 is essential for lymphocyte activation [J].
Hara, H ;
Wada, T ;
Bakal, C ;
Kozieradzki, I ;
Suzuki, S ;
Suzuki, N ;
Nghiem, M ;
Griffiths, EK ;
Krawczyk, C ;
Bauer, B ;
D'Acquisto, F ;
Ghosh, S ;
Yeh, WC ;
Baier, G ;
Rottapel, R ;
Penninger, JM .
IMMUNITY, 2003, 18 (06) :763-775
[5]   Identifying the MAGUK protein CARMA-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis [J].
Jun, JE ;
Wilson, LE ;
Vinuesa, CG ;
Lesage, S ;
Blery, M ;
Miosge, LA ;
Cook, MC ;
Kucharska, EM ;
Hara, H ;
Penninger, JM ;
Domashenz, H ;
Hong, NA ;
Glynne, RJ ;
Nelms, KA ;
Goodnow, CC .
IMMUNITY, 2003, 18 (06) :751-762
[6]   Phosphorylation meets ubiquitination:: The control of NF-κB activity [J].
Karin, M ;
Ben-Neriah, Y .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :621-+
[7]   Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-κB signaling pathway [J].
Lucas, PC ;
Yonezumi, M ;
Inohara, N ;
McAllister-Lucas, LM ;
Abazeed, ME ;
Chen, FF ;
Yamaoka, S ;
Seto, M ;
Núñez, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (22) :19012-19019
[8]   Marginal-zone B cells [J].
Martin, F ;
Kearney, JF .
NATURE REVIEWS IMMUNOLOGY, 2002, 2 (05) :323-335
[9]   Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-κB induction [J].
McAllister-Lucas, LM ;
Inohara, N ;
Lucas, PC ;
Ruland, J ;
Benito, A ;
Li, QT ;
Chen, S ;
Chen, FF ;
Yamaoka, S ;
Verma, IM ;
Mak, TW ;
Núñez, G .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (33) :30589-30597
[10]   Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes [J].
Newton, K ;
Dixit, VM .
CURRENT BIOLOGY, 2003, 13 (14) :1247-1251