Synthesis of nitric oxide-releasing gold nanoparticles

被引:110
作者
Rothrock, AR [1 ]
Donkers, RL [1 ]
Schoenfisch, MH [1 ]
机构
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
关键词
D O I
10.1021/ja052027u
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report the synthesis of nitric oxide-releasing gold nanoparticles formed by place-exchange reaction of hexanethiol monolayer-protected clusters with diamine nitric oxide donor precursor molecules, which are subsequently converted to N-diazeniumdiolate NO donors. The nitric oxide release from the N-diazeniumdiolate-modified gold nanoparticles is tunable by varying the number and/or the chemical structure of the exchanged amine ligands. The size and stability of NO-releasing nanoparticles may prove useful for a range of biomedical and pharmaceutical applications. Copyright © 2005 American Chemical Society.
引用
收藏
页码:9362 / 9363
页数:2
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