Polymers incorporating nitric oxide releasing/generating substances for improved biocompatibility of blood-contactincy medical devices

被引:275
作者
Frost, MC [1 ]
Reynolds, MM [1 ]
Meyerhoff, ME [1 ]
机构
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
关键词
nitric oxide; blood compatible polymers; anti-platelet activity;
D O I
10.1016/j.biomaterials.2004.06.006
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The current state-of-the-art with respect to the preparation, characterization and biomedical applications of novel nitric oxide (NO) releasing or generating polymeric materials is reviewed. Such materials show exceptional promise as coatings to prepare a new generation of medical devices with superior biocompatiblity. Nitric oxide is a well-known inhibitor of platelet adhesion and activation, as well as a potent inhibitor of smooth muscle cell proliferation. Hence, polymers that release OF generate NO locally at their surface exhibit greatly enhanced thromboresistivity and have the potential to reduce neointimal hyperplasia caused by device damage to blood vessel walls. In this review, the use of diazeniumdiolates and nitrosothiols as NO donors within a variety polymeric matrixes are summarized. Such species can either be doped as discrete NO donors within polymeric films, or covalently baked to polymer backbones and/or inorganic polymeric filler particles that are often employed to enhance the strength of biomedical polymers (e.g., fumed silica or titanium dioxide). In addition, very recent efforts to create catalytic polymers posssessing immobilized Cu(II) sites capable of generating NO from endogenous oxidized forms of NNO already present in blood and other physiological fluids (nitrite and nitrosothiols) are discussed. Preliminary literature data illustrating the efficacy of the various NO release/ generating polymers as coatings for intravascular sensors, extracorporeal blood loop circuits. and arteriovenous grafts/shunts are reviewed. circle * 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1685 / 1693
页数:9
相关论文
共 73 条
  • [1] Reduced platelet activation and thrombosis in extracorporeal circuits coated with nitric oxide release polymers
    Annich, GM
    Meinhardt, JP
    Mowery, KA
    Ashton, BA
    Merz, SI
    Hirschl, RB
    Meyerhoff, ME
    Bartlett, RH
    [J]. CRITICAL CARE MEDICINE, 2000, 28 (04) : 915 - 920
  • [2] MODIFICATION OF BIOMATERIALS TO IMPROVE BLOOD COMPATIBILITY
    BAMFORD, CH
    MIDDLETON, IP
    ALLAMEE, KG
    PAPROTNY, JJ
    [J]. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 1992, 15 (02) : 71 - 78
  • [3] More lipophilic dialkyldiamine-based diazeniumdiolates: Synthesis, characterization, and application in preparing thromboresistant nitric oxide release polymeric coatings
    Batchelor, MM
    Reoma, SL
    Fleser, PS
    Nuthakki, VK
    Callahan, RE
    Shanley, CJ
    Politis, JK
    Elmore, J
    Merz, SI
    Meyerhoff, ME
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (24) : 5153 - 5161
  • [4] BATCHELOR MM, 2004, THESIS U MICHIGAN, P157
  • [5] Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation
    Bohl, KS
    West, JL
    [J]. BIOMATERIALS, 2000, 21 (22) : 2273 - 2278
  • [6] BRAYBROOK J, 1997, WIL SER BIOM SCI ENG, P21
  • [7] Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells
    Bruemmer, D
    Yin, F
    Liu, J
    Kiyono, T
    Fleck, E
    Van Herle, AJ
    Law, RE
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 303 (01) : 251 - 258
  • [8] Platelets and restenosis
    Chandrasekar, B
    Tanguay, JF
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (03) : 555 - 562
  • [9] Perivascular delivery of a nitric oxide donor inhibits neointimal hyperplasia in vein grafts implanted in the arterial circulation
    Chaux, A
    Ruan, XM
    Fishbein, MC
    Yi, OY
    Kaul, S
    Pass, JA
    Matloff, JM
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1998, 115 (03) : 604 - 612
  • [10] Boundary layer infusion of nitric oxide reduces early smooth muscle cell proliferation in the endarterectomized canine artery
    Chen, CY
    Hanson, SR
    Keefer, LK
    Saavedra, JE
    Davies, KM
    Hutsell, TC
    Hughes, JD
    Ku, DN
    Lumsden, AB
    [J]. JOURNAL OF SURGICAL RESEARCH, 1997, 67 (01) : 26 - 32