Does tumor growth follow a "universal law"?

被引:189
作者
Guiot, C
Degiorgis, PG
Delsanto, PP
Gabriele, P
Deisboeck, TS
机构
[1] Univ Turin, INFM, Dept Neurosci, I-10125 Turin, Italy
[2] Sez Torino Univ & Politecn, INFM, Turin, Italy
[3] Politecn Torino, Dip Fis, Turin, Italy
[4] IRCC Candiolo, Turin, Italy
[5] Harvard Univ, HST Biomed Engn Ctr, Athinula A Martinos Ctr Biomed Imaging, MIT,Complex Biosyst Modeling Lab, Cambridge, MA 02139 USA
[6] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Mol Neurooncol Lab, Boston, MA 02129 USA
关键词
tumor growth kinetics; tumor therapy; methametical modelling; universal law; metastasis; angiogenesis; invasion;
D O I
10.1016/S0022-5193(03)00221-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a "universal" law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion. (C) 2003 Published by Elsevier Ltd.
引用
收藏
页码:147 / 151
页数:5
相关论文
共 26 条
[1]   HUMAN-MALIGNANT ASTROCYTOMA XENOGRAFTS MIGRATE IN RAT-BRAIN - A MODEL FOR CENTRAL NERVOUS-SYSTEM CANCER-RESEARCH [J].
BERNSTEIN, JJ ;
GOLDBERG, WJ ;
LAWS, ER .
JOURNAL OF NEUROSCIENCE RESEARCH, 1989, 22 (02) :134-143
[2]   Forecasting the growth of multicell tumour spheroids: implications for the dynamic growth of solid tumours [J].
Chignola, R ;
Schenetti, A ;
Andrighetto, G ;
Chiesa, E ;
Foroni, R ;
Sartoris, S ;
Tridente, G ;
Liberati, D .
CELL PROLIFERATION, 2000, 33 (04) :219-229
[3]   Radiosensitization by oxaliplatin in a mouse adenocarcinoma: Influence of treatment schedule [J].
Cividalli, A ;
Ceciarelli, F ;
Livdi, E ;
Altavista, P ;
Cruciani, G ;
Marchetti, P ;
Danesi, DT .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2002, 52 (04) :1092-1098
[4]   Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model [J].
Deisboeck, TS ;
Berens, ME ;
Kansal, AR ;
Torquato, S ;
Stemmer-Rachamimov, AO ;
Chiocca, EA .
CELL PROLIFERATION, 2001, 34 (02) :115-134
[5]   Analysis of a "phase transition" from tumor growth to latency [J].
Delsanto, PP ;
Romano, A ;
Scalerandi, M ;
Pescarmona, GP .
PHYSICAL REVIEW E, 2000, 62 (02) :2547-2554
[6]  
DELSANTO PP, 2003, UNPUB PHYS REV LETT
[7]  
FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182
[8]  
FREYER JP, 1986, CANCER RES, V46, P3504
[9]   THE EFFECT OF LOCAL-CONTROL ON METASTATIC DISSEMINATION IN CARCINOMA OF THE PROSTATE - LONG-TERM RESULTS IN PATIENTS TREATED WITH I-125 IMPLANTATION [J].
FUKS, Z ;
LEIBEL, SA ;
WALLNER, KE ;
BEGG, CB ;
FAIR, WR ;
ANDERSON, LL ;
HILARIS, BS ;
WHITMORE, WF .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 21 (03) :537-547
[10]  
Nirmala C, 2001, INT J ONCOL, V19, P1109