Does tumor growth follow a "universal law"?

被引：189

作者：

Guiot, C

Degiorgis, PG

Delsanto, PP

Gabriele, P

Deisboeck, TS

机构：

[1] Univ Turin, INFM, Dept Neurosci, I-10125 Turin, Italy

[2] Sez Torino Univ & Politecn, INFM, Turin, Italy

[3] Politecn Torino, Dip Fis, Turin, Italy

[4] IRCC Candiolo, Turin, Italy

[5] Harvard Univ, HST Biomed Engn Ctr, Athinula A Martinos Ctr Biomed Imaging, MIT,Complex Biosyst Modeling Lab, Cambridge, MA 02139 USA

[6] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Mol Neurooncol Lab, Boston, MA 02129 USA

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2003年 / 225卷 / 02期

关键词：

tumor growth kinetics; tumor therapy; methametical modelling; universal law; metastasis; angiogenesis; invasion;

D O I：

10.1016/S0022-5193(03)00221-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A general model for the ontogenetic growth of living organisms has been recently proposed. Here we investigate the extension of this model to the growth of solid malignant tumors. A variety of in vitro and in vivo data are analysed and compared with the prediction of a "universal" law, relating properly rescaled tumor masses and tumor growth times. The results support the notion that tumor growth follows such a universal law. Several important implications of this finding are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion. (C) 2003 Published by Elsevier Ltd.

引用

页码：147 / 151

页数：5

共 26 条

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