T-cell recognition of non-peptide antigens

被引：75

作者：

Porcelli, SA

Morita, CT

Modlin, RL

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DIV DERMATOL,LOS ANGELES,CA 90095

[2] BRIGHAM & WOMENS HOSP,DIV RHEUMATOL & IMMUNOL,BOSTON,MA 02115

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90095

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(96)80039-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Studies of two distinct human T-cell systems have provided the exciting finding that T cells are able to recognize non-peptide antigens: gamma delta T cells have been shown to recognize isopentenyl pyrophosphate and related structures and human CD1 has been shown to present microbial lipids and lipoglycans such as mycolic acids and lipoarabinomannan to T cells. T-cell responses to these non-peptide antigens should provide a strategic target for immunologic intervention in infectious disease.

引用

页码：510 / 516

页数：7

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