STIMULATION OF HUMAN GAMMA-DELTA T-CELLS BY NONPEPTIDIC MYCOBACTERIAL LIGANDS

被引：656

作者：

CONSTANT, P

DAVODEAU, F

PEYRAT, MA

POQUET, Y

PUZO, G

BONNEVILLE, M

FOURNIE, JJ

机构：

[1] CNRS,PHARMACOL & TOXICOL FONDAMENTALES LAB,DEPT 3,118 RTE NARBONNE,F-31062 TOULOUSE,FRANCE

[2] INST BIOL,INSERM,U211,F-44035 NANTES,FRANCE

来源：

SCIENCE | 1994年 / 264卷 / 5156期

关键词：

D O I：

10.1126/science.8146660

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most human peripheral blood gammadelta T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human gammadelta T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5' triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some gammadelta T cells recognize nonpeptidic ligands.

引用

页码：267 / 270

页数：4

共 27 条

[1] RESIDENT PULMONARY LYMPHOCYTES EXPRESSING THE GAMMA-DELTA T-CELL RECEPTOR
AUGUSTIN, A
KUBO, RT
SIM, GK
[J]. NATURE, 1989, 340 (6230) : 239 - 241
[2] BORN W, 1990, IMMUNOL TODAY, V11, P40
[3] RECOGNITION OF A PEPTIDE ANTIGEN BY HEAT-SHOCK REACTIVE GAMMA-DELTA-LYMPHOCYTES-T
BORN, W
HALL, L
DALLAS, A
BOYMEL, J
SHINNICK, T
YOUNG, D
BRENNAN, P
OBRIEN, R
[J]. SCIENCE, 1990, 249 (4964) : 67 - 69
[4] BREITMAIER E, 1987, CARBON 13 NMR SPECTR, P401
[5] CONSTANT P, UNPUB
[6] DAVODEAU F, 1993, J IMMUNOL, V151, P1214
[7] DAVODEAU F, 1993, J BIOL CHEM, V268, P15455
[8] DAVODEAU F, UNPUB
[9] RECOGNITION BY HUMAN V-GAMMA-9/V-DELTA-2 T-CELLS OF A GROEL HOMOLOG ON DAUDI-BURKITT LYMPHOMA-CELLS
FISCH, P
MALKOVSKY, M
KOVATS, S
STURM, E
BRAAKMAN, E
KLEIN, BS
VOSS, SD
MORRISSEY, LW
DEMARS, R
WELCH, WJ
BOLHUIS, RLH
SONDEL, PM
[J]. SCIENCE, 1990, 250 (4985) : 1269 - 1273
[10] FISCH P, 1992, J IMMUNOL, V148, P2315

← 1 2 3 →