Notch signaling: direct or what?

被引：94

作者：

Weinmaster, G ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(98)80115-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechanism(s) by which Notch signaling produces so many outcomes remains unclear.

引用

页码：436 / 442

页数：7

共 66 条

[51] Notch in vertebrates [J].

Robey, E .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1997, 7 (04) :551-557

[52] KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis [J].

Rooke, J ;

Pan, D ;

Xu, T ;

Rubin, GM .

SCIENCE, 1996, 273 (5279) :1227-1231

[53] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain [J].

Schroeter, EH ;

Kisslinger, JA ;

Kopan, R .

NATURE, 1998, 393 (6683) :382-386

[54]

Shawber C, 1996, DEVELOPMENT, V122, P3765

[55]

Sotillos S, 1997, DEVELOPMENT, V124, P4769

[56]

SPEICHER SA, 1994, DEVELOPMENT, V120, P535

[57] Nuclear access and action of notch in vivo [J].

Struhl, G ;

Adachi, A .

CELL, 1998, 93 (04) :649-660

[58]

Sun X, 1996, DEVELOPMENT, V122, P2465

[59] Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H) [J].

Tamura, K ;

Taniguchi, Y ;

Minoguchi, S ;

Sakai, T ;

Tun, T ;

Furukawa, T ;

Honjo, T .

CURRENT BIOLOGY, 1995, 5 (12) :1416-1423

[60]

TEPASS U, 1995, DEVELOPMENT, V121, P393

← 1 2 3 4 5 6 7 →