The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum

被引：15

作者：

Cebrian-Torrejon, Gerardo ^{[1
]}

Spelman, Kevin ^{[2
]}

Leblanc, Karine ^{[1
]}

Munoz-Durango, Katalina ^{[1
]}

Gutierrez, Sandra Torijano ^{[1
]}

Ferreira, Maria Elena ^{[3
]}

de Arias, Antonieta Rojas ^{[4
]}

Figadere, Bruno ^{[1
]}

Fournet, Alain ^{[1
]}

Maciuk, Alexandre ^{[1
]}

Grellier, Philippe ^{[5
]}

Cech, Nadja B. ^{[6
]}

Poupon, Erwan ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, Lab Pharmacognosie, CNRS,UMR BioCIS 8076, F-92296 Chatenay Malabry, France

[2] NIA, Bioanalyt Chem & Drug Discovery Sect, Clin Invest Lab, NIH, Bethesda, MD 20892 USA

[3] Univ Nacl Asuncion, Inst Invest Ciencias Salud Asuncion, Dept Trop Med, San Lorenzo, Paraguay

[4] Ctr Desarrollo Invest Cient CEDIC FMB Diaz Gill M, Asuncion, Paraguay

[5] Museum Natl Hist Nat, CNRS, Dept Reg Dev & Diversite Mol, FRE 3206, Paris, France

[6] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27412 USA

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2011年 / 21卷 / 04期

关键词：

alkylamides; avicennol; canthinone alkaloids; Heme-drug adducts; Plasmodium falciparum; Zanthoxylum chiloperone; HIGH-THROUGHPUT SCREEN; CANTHIN-6-ONE ALKALOIDS; ANTIMALARIAL; MALARIA; HEME; CONSTITUENTS; ALKYLAMIDES; GROWTH; PLANTS; ASSAY;

D O I：

10.1590/S0102-695X2011005000104

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Zanthoxylum chiloperone var. angustifolium Engl., Rutaceae, is used in traditional medicine to treat fungal and protozoal infections in the central area of South America. Considering the increasing resistance of Plasmodium falciparum in malarial ridden areas, we explored the anti-plasmodial effects of three compounds isolated from Z. chiloperone. The pyranocoumarin trans-avicennol and the canthinone alkaloids, canthin-6-one and 5-methoxycanthin-6-one, were found to have IC50 on chloroquine/mefloquine resistant and sensitive strains of P. falciparum of 0.5-2.7, 2.0-5.3 and 5.1-10.4 mu g/mL, respectively. Moreover, the formation of heme adducts by these compounds is described by a novel alternative method based on MS-CID methods. The alkylamide sanshool was also identified, for first time in this plant, in the dichloromethanic and ethanolic extracts and the extracts were found to be notably non-toxic and displayed good anti-plasmodial effects.

引用

页码：652 / 661

页数：10

共 34 条

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Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin -: Its application to Artemisia annua constituents [J].