Effects of piperaquine, chloroquine, and amodiaquine on drug uptake and of these in combination with dihydroartemisinin against drug-sensitive and -resistant Plasmodium falciparum strains

被引：22

作者：

Fivelman, Quinton L. ^{[1
]}

Adagu, Ipemida S. ^{[1
]}

Warhurst, David C. ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期

关键词：

D O I：

10.1128/AAC.01479-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Piperaquine is being developed as a long-acting component in artemisinin combination therapies. It was highly active in vitro and drug interaction studies showed that dihydroartemisinin combinations with piperaquine, chloroquine, and amodiaquine were indifferent tending toward antagonism. Competitive uptake of radiolabeled chloroquine and dihydroartemisinin in combination with other antimalarials was observed.

引用

页码：2265 / 2267

页数：3

共 22 条

[1] In vitro activities of piperaquine and other 4-aminoquinolines against clinical isolates of Plasmodium falciparum in Cameroon [J].

Basco, LK ;

Ringwald, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (04) :1391-1394

[2] Access to hematin: The basis of chloroquine resistance [J].

Bray, PG ;

Mungthin, M ;

Ridley, RG ;

Ward, SA .

MOLECULAR PHARMACOLOGY, 1998, 54 (01) :170-179

[3] Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum [J].

Bray, PG ;

Janneh, O ;

Raynes, KJ ;

Mungthin, M ;

Ginsburg, H ;

Ward, SA .

JOURNAL OF CELL BIOLOGY, 1999, 145 (02) :363-376

[4]

CHAWIRA AN, 1987, J TROP MED HYG, V90, P1

[5]

CHEN L, 1991, CHINESE MED J-PEKING, V104, P161

[6] FERRIPROTOPORPHYRIN-IX FULFILLS THE CRITERIA FOR IDENTIFICATION AS THE CHLOROQUINE RECEPTOR OF MALARIA PARASITES [J].

CHOU, AC ;

CHEVLI, R ;

FITCH, CD .

BIOCHEMISTRY, 1980, 19 (08) :1543-1549

[7] In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs [J].

Davis, Timothy M. E. ;

Hamzah, Juliana ;

Ilett, Kenneth F. ;

Karunajeewa, Harin A. ;

Reeder, John C. ;

Batty, Kevin T. ;

Hackett, Sara ;

Barrett, P. Hugh R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (08) :2883-2885

[8]

Fidock DA, 2000, MOL CELL, V6, P861, DOI 10.1016/S1097-2765(05)00077-8

[9] PLASMODIUM FALCIPARUM IN OWL MONKEYS - DRUG RESISTANCE AND CHLOROQUINE BINDING CAPACITY [J].

FITCH, CD .

SCIENCE, 1970, 169 (3942) :289-+

[10] The effect of artesunate combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium faiciparum in vitro [J].

Fivelman, QL ;

Walden, JC ;

Smith, PJ ;

Folb, PI ;

Barnes, KI .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1999, 93 (04) :429-432

← 1 2 3 →