SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

被引：1843

作者：

Sungnak, Waradon ^{[1
]}

Huang, Ni ^{[1
]}

Becavin, Christophe ^{[2
]}

Berg, Marijn ^{[3
,4
,5
]}

Queen, Rachel ^{[6
]}

Litvinukova, Monika ^{[1
,7
]}

Talavera-Lopez, Carlos ^{[1
]}

Maatz, Henrike ^{[7
]}

Reichart, Daniel ^{[8
]}

Sampaziotis, Fotios ^{[9
,10
,11
]}

Worlock, Kaylee B. ^{[12
]}

Yoshida, Masahiro ^{[12
]}

Barnes, Josephine L. ^{[12
]}

机构：

[1] Wellcome Sanger Inst, Cambridge, England

[2] Univ Cote Azur, CNRS, IPMC, Sophia Antipolis, France

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma, Groningen, Netherlands

[5] Univ Groningen, Univ Med Ctr Groningen, COPD, Groningen, Netherlands

[6] Newcastle Univ, Fac Med Sci, Biosci Inst, Bioinformat Core Facil, Newcastle Upon Tyne, Tyne & Wear, England

[7] Helmholtz Assoc MDC, Max Delbruck Ctr Mol Med, Cardiovasc & Metab Sci, Berlin, Germany

[8] Harvard Med Sch, Dept Genet, Boston, MA 02115 USA

[9] Univ Cambridge, Wellcome & MRC Cambridge Stem Cell Inst, Cambridge, England

[10] Addenbrookes Hosp, Dept Med, Cambridge, England

[11] Cambridge Univ Hosp, Cambridge Liver Unit, Cambridge, England

[12] UCL, Div Med, UCL Resp, London, England

来源：

NATURE MEDICINE | 2020年 / 26卷 / 05期

基金：

中国国家自然科学基金; 奥地利科学基金会; 英国生物技术与生命科学研究理事会; 新加坡国家研究基金会; 英国医学研究理事会; 欧盟地平线“2020”; 英国国家替代、减少和改良动物研究中心; 英国工程与自然科学研究理事会; 美国国家卫生研究院; 英国惠康基金;

关键词：

FUNCTIONAL RECEPTOR; CORONAVIRUS; PROTEIN; ACE2;

D O I：

10.1038/s41591-020-0868-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

引用

页码：681 / +

页数：12

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