Immunobiology of muscle: advances in understanding an immunological microenvironment

被引:139
作者
Wiendl, H
Hohlfeld, R
Kieseier, BC
机构
[1] Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany
[2] Univ Munich, Inst Clin Neuroimmunol, D-81377 Munich, Germany
[3] Univ Dusseldorf, Dept Neurol, D-40225 Dusseldorf, Germany
关键词
D O I
10.1016/j.it.2005.05.003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Skeletal muscle, which is the largest cellular compartment of the body, lacks detectable MHC expression under physiological conditions. Therefore, immune reactions triggered by, or directed against, muscle cells proceed along specific pathways. Recently, the expression and functioning of classical MHC, nonclassical MHC, adhesion and co-stimulatory molecules have been shown to support the concept that muscle cells can act as facultative antigen-presenting cells and should be considered as active participants, rather than passive targets, of immune reactions. Here, we summarize current knowledge on the immunological capabilities of skeletal muscle cells and discuss how these characteristics might contribute to inflammatory muscle disorders, as well as therapeutic strategies, such as gene or myoblast transfer.
引用
收藏
页码:373 / 380
页数:8
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