Class A scavenger receptors and the phagocytosis of apoptotic cells

被引：35

作者：

Platt, N ^{[1
]}

da Silva, RP ^{[1
]}

Gordon, S ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

IMMUNOLOGY LETTERS | 1999年 / 65卷 / 1-2期

关键词：

scavenger receptor; macrophage; phagocytosis; apoptosis;

D O I：

10.1016/S0165-2478(98)00118-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptotic cells are rarely seen in situ because of rapid clearance by phagocytes. A number of receptors have been implicated in the recognition and ingestion of dying cells. Class A scavenger receptors (SRs) are multi-domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. There is growing evidence that they contribute to several biological processes. We present data that suggest class A SRs are involved in the phagocytosis of apoptotic cells. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：15 / 19

页数：5

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