Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans

Animal model and clinical studies indicate that type 1 diabetes (T1D) results from T cell-mediated autoimmune destruction of insulin-producing pancreatic beta-cells. This review discusses the knowledge gained from animal models about the nature of the autoreactive T cells that cause T1D and the possible basis for their development. Based on this information, the possible positive and negative aspects of various antigen-specific and nonspecific immunotherapies, which could potentially prevent the onset of T1D in at risk individuals, are discussed.