Anesthetic-sensitive 2P domain K+ channels

被引：87

作者：

Patel, AJ ^{[1
]}

Honoré, E ^{[1
]}

机构：

[1] Inst Pharmacol Mol & Cellulaire, CNRS UMR6097, F-06560 Valbonne, France

来源：

ANESTHESIOLOGY | 2001年 / 95卷 / 04期

关键词：

D O I：

10.1097/00000542-200110000-00034

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Volatile anesthetic-mediated hyperpolarization reduces excitability, increases synaptic input conductance, and may contribute to the depression of the central nervous system, whereas local anesthetic-mediated depolarization may enhance the conduction block of peripheral nerves. Background K+ channels, which are encoded by the newly discovered family of 2P domain K+ channel subunits, are the targets of volatile as well as local anesthetics.

引用

页码：1013 / 1021

页数：9

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