CDD: NCBI's conserved domain database

被引：2643

作者：

Marchler-Bauer, Aron ^{[1
]}

Derbyshire, Myra K. ^{[1
]}

Gonzales, Noreen R. ^{[1
]}

Lu, Shennan ^{[1
]}

Chitsaz, Farideh ^{[1
]}

Geer, Lewis Y. ^{[1
]}

Geer, Renata C. ^{[1
]}

He, Jane ^{[1
]}

Gwadz, Marc ^{[1
]}

Hurwitz, David I. ^{[1
]}

Lanczycki, Christopher J. ^{[1
]}

Lu, Fu ^{[1
]}

Marchler, Gabriele H. ^{[1
]}

Song, James S. ^{[1
]}

Thanki, Narmada ^{[1
]}

Wang, Zhouxi ^{[1
]}

Yamashita, Roxanne A. ^{[1
]}

Zhang, Dachuan ^{[1
]}

Zheng, Chanjuan ^{[1
]}

Bryant, Stephen H. ^{[1
]}

机构：

[1] NIH, Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/nar/gku1221

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NCBI's CDD, the Conserved Domain Database, enters its 15(th) year as a public resource for the annotation of proteins with the location of conserved domain footprints. Going forward, we strive to improve the coverage and consistency of domain annotation provided by CDD. We maintain a live search system as well as an archive of pre-computed domain annotation for sequences tracked in NCBI's Entrez protein database, which can be retrieved for single sequences or in bulk. We also maintain import procedures so that CDD contains domain models and domain definitions provided by several collections available in the public domain, as well as those produced by an in-house curation effort. The curation effort aims at increasing coverage and providing finer-grained classifications of common protein domains, for which a wealth of functional and structural data has become available. CDD curation generates alignment models of representative sequence fragments, which are in agreement with domain boundaries as observed in protein 3D structure, and which model the structurally conserved cores of domain families as well as annotate conserved features.

引用

页码：D222 / D226

页数：5

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