CD-Search: protein domain annotations on the fly

被引：1583

作者：

Marchler-Bauer, A ^{[1
]}

Bryant, SH ^{[1
]}

机构：

[1] NCBI, Computat Biol Branch, Natl Lib Med, NIH, Bethesda, MD 20894 USA

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/nar/gkh454

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the Conserved Domain Search service (CD-Search), a web-based tool for the detection of structural and functional domains in protein sequences. CD-Search uses BLAST(R) heuristics to provide a fast, interactive service, and searches a comprehensive collection of domain models. Search results are displayed as domain architecture cartoons and pairwise alignments between the query and domain-model consensus sequences. Search results may be visualized in further detail by embedding the query sequence into multiple alignment displays and by mapping onto three-dimensional molecular graphic displays of known structures within the domain family. CD-Search can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi.

引用

页码：W327 / W331

页数：5

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