SMART 4.0: towards genomic data integration

被引：824

作者：

Letunic, I

Copley, RR

Schmidt, S

Ciccarelli, FD

Doerks, T

Schultz, J

Ponting, CP

Bork, P

机构：

[1] European Mol Biol Lab, D-69012 Heidelberg, Germany

[2] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[3] Univ Wurzburg, Biozentrum, D-97074 Wurzburg, Germany

[4] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England

来源：

NUCLEIC ACIDS RESEARCH | 2004年 / 32卷

关键词：

D O I：

10.1093/nar/gkh088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SMART (Simple Modular Architecture Research Tool) is a web tool (http://smart.embl.de/) for the identification and annotation of protein domains, and provides a platform for the comparative study of complex domain architectures in genes and proteins. The January 2004 release of SMART contains 685 protein domains. New developments in SMART are centred on the integration of data from completed metazoan genomes. SMART now uses predicted proteins from complete genomes in its source sequence databases, and integrates these with predictions of orthology. New visualization tools have been developed to allow analysis of gene intron-exon structure within the context of protein domain structure, and to align these displays to provide schematic comparisons of orthologous genes, or multiple transcripts from the same gene. Other improvements include the ability to query SMART by Gene Ontology terms, improved structure database searching and batch retrieval of multiple entries.

引用

页码：D142 / D144

页数：3

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