[(Cy)Ru(LL*)Cl] and related half-sandwich compounds - two diastereomers in the same single crystal

被引：39

作者：

Brunner, H ^{[1
]}

Weber, M ^{[1
]}

Zabel, M ^{[1
]}

机构：

[1] Univ Regensburg, Inst Anorgan Chem, D-93040 Regensburg, Germany

来源：

COORDINATION CHEMISTRY REVIEWS | 2003年 / 242卷 / 1-2期

关键词：

enantiomers; diastereomers; half-sandwich complexes; 1 : 1 diastereomer co-crystallization; molecular recognition;

D O I：

10.1016/S0010-8545(03)00024-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The ruthenium compound [(Cy)Ru(LL*)Cl] (1) crystallizes as a 1:1 mixture of the two diastereomers (R-Ru,S-C)-1 and (S-Ru,Sc)-1 in the same single crystal, whereas the corresponding osmium compound [(Cy)Os(LL*)Cl] (2), almost identical to 1 in the molecular parameters, crystallizes as the pure diastereomer (R-Os,S-C)-2. 1:1 diastereomer co-crystallization is traced back to a molecular recognition motif, the pair formation of fragments (Ar)MXY, in which X and Y are electronegative substituents. Thus, compounds of the type [(Ar)MXYZ], in particular (Cy)Ru derivatives, tend to form inversion pairs of enantiomers and also of diastereomers. Fifteen cases of 1:1 diastereomer co-crystallization in half-sandwich complexes are presented. The discussion is extended to [(Cy)RuLCl2] and related complexes. It is shown that there is a delicate balance between 1:1 diastereomer co-crystallization and crystallization as a pure diastereomer. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：3 / 13

页数：11

共 41 条

[1]

ADDADI L, 1976, ISRAEL J CHEM, V15, P116

[2] [Ru(η6-p-cymene)Cl2(pta)] (pta=1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane):: a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells [J].

Allardyce, CS ;

Dyson, PJ ;

Ellis, DJ ;

Heath, SL .

CHEMICAL COMMUNICATIONS, 2001, (15) :1396-1397

[3] (η6-arene)ruthenium(II) complexes containing enantiomerically pure (β-aminoalkyl)phosphines or a (β-aminoalkyl) phosphinite:: synthesis, stereochemical and kinetic studies [J].

Arena, CG ;

Calamia, S ;

Faraone, F ;

Graiff, C ;

Tiripicchio, A .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2000, (18) :3149-3157

[4] Diastereoselectivity of chloride substitution reactions of cycloruthenated (R)(c)-(+)- and (S)(c)-(-)-dimethyl(1-phenylethyl)amine [J].

Attar, S ;

Catalano, VJ ;

Nelson, JH .

ORGANOMETALLICS, 1996, 15 (13) :2932-2946

[5]

Brunner H, 1997, ENANTIOMER, V2, P133

[6]

Brunner H, 2001, EUR J INORG CHEM, P905

[7] Optically active transition metal complexes .107. Synthesis, properties, stereochemistry and crystal structures of diastereomeric benzene-ruthenium(II) complexes with a chiral salicylideneaminato ligand [J].

Brunner, H ;

Oeschey, R ;

Nuber, B .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1996, (08) :1499-1508

[8]

Brunner H, 1998, EUR J INORG CHEM, P1877

[9] PROPELLER ISOMERISM OF THE TRIPHENYLPHOSPHANE LIGAND IN HALF-SANDWICH RU-II COMPLEXES [J].

BRUNNER, H ;

OESCHEY, R ;

NUBER, B .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (08) :866-868

[10]

BRUNNER H, IN PRESS POLYHEDRON

← 1 2 3 4 5 →