UniProt: a hub for protein information

被引：3549

作者：

Bateman, Alex ^{[1
]}

Martin, Maria Jesus ^{[1
]}

O'Donovan, Claire ^{[1
]}

Magrane, Michele ^{[1
]}

Apweiler, Rolf ^{[1
]}

Alpi, Emanuele ^{[1
]}

Antunes, Ricardo ^{[1
]}

Arganiska, Joanna ^{[1
]}

Bely, Benoit ^{[1
]}

Bingley, Mark ^{[1
]}

Bonilla, Carlos ^{[1
]}

Britto, Ramona ^{[1
]}

Bursteinas, Borisas ^{[1
]}

Chavali, Gayatri ^{[1
]}

Cibrian-Uhalte, Elena ^{[1
]}

Da Silva, Alan ^{[1
]}

De Giorgi, Maurizio ^{[1
]}

Dogan, Tunca ^{[1
]}

Fazzini, Francesco ^{[1
]}

Gane, Paul ^{[1
]}

Cas-tro, Leyla Garcia ^{[1
]}

Garmiri, Penelope ^{[1
]}

Hatton-Ellis, Emma ^{[1
]}

Hieta, Reija ^{[1
]}

Huntley, Rachael ^{[1
]}

Legge, Duncan ^{[1
]}

Liu, Wudong ^{[1
]}

Luo, Jie ^{[1
]}

MacDougall, Alistair ^{[1
]}

Mutowo, Prudence ^{[1
]}

Nightin-gale, Andrew ^{[1
]}

Orchard, Sandra ^{[1
]}

Pichler, Klemens ^{[1
]}

Poggioli, Diego ^{[1
]}

Pundir, Sangya ^{[1
]}

Pureza, Luis ^{[1
]}

Qi, Guoying ^{[1
]}

Rosanoff, Steven ^{[1
]}

Saidi, Rabie ^{[1
]}

Sawford, Tony ^{[1
]}

Shypitsyna, Aleksandra ^{[1
]}

Turner, Edward ^{[1
]}

Volynkin, Vladimir ^{[1
]}

Wardell, Tony ^{[1
]}

Watkins, Xavier ^{[1
]}

Zellner, Hermann ^{[1
]}

Cowley, Andrew ^{[1
]}

Figueira, Luis ^{[1
]}

Li, Weizhong ^{[1
]}

McWilliam, Hamish ^{[1
]}

机构：

[1] European Bioinformat Inst, European Mol Biol Lab, Cambridge CB10 1SD, England

[2] SIB Swiss Inst Bioinformat, Ctr Med Univ, CH-1211 Geneva 4, Switzerland

[3] Georgetown Univ, Med Ctr, Prot Informat Resource, Washington, DC 20007 USA

[4] Univ Delaware, Prot Informat Resource, Newark, DE 19711 USA

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

DATABASE; ANNOTATION;

D O I：

10.1093/nar/gku989

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

UniProt is an important collection of protein sequences and their annotations, which has doubled in size to 80 million sequences during the past year. This growth in sequences has prompted an extension of UniProt accession number space from 6 to 10 characters. An increasing fraction of new sequences are identical to a sequence that already exists in the database with the majority of sequences coming from genome sequencing projects. We have created a new proteome identifier that uniquely identifies a particular assembly of a species and strain or subspecies to help users track the provenance of sequences. We present a new website that has been designed using a user-experience design process. We have introduced an annotation score for all entries in UniProt to represent the relative amount of knowledge known about each protein. These scores will be helpful in identifying which proteins are the best characterized and most informative for comparative analysis. All UniProt data is provided freely and is available on the web at http://www.uniprot.org/.

引用

页码：D204 / D212

页数：9

共 18 条

[1] Rhea-a manually curated resource of biochemical reactions
Alcantara, Rafael
Axelsen, Kristian B.
Morgat, Anne
Belda, Eugeni
Coudert, Elisabeth
Bridge, Alan
Cao, Hong
de Matos, Paula
Ennis, Marcus
Turner, Steve
Owen, Gareth
Bougueleret, Lydie
Xenarios, Ioannis
Steinbeck, Christoph
[J]. NUCLEIC ACIDS RESEARCH, 2012, 40 (D1) : D754 - D760
[2] Representative Proteomes: A Stable, Scalable and Unbiased Proteome Set for Sequence Analysis and Functional Annotation
Chen, Chuming
Natale, Darren A.
Finn, Robert D.
Huang, Hongzhan
Zhang, Jian
Wu, Cathy H.
Mazumder, Raja
[J]. PLOS ONE, 2011, 6 (04):
[3] The UniProt-GO Annotation database in 2011
Dimmer, Emily C.
Huntley, Rachael P.
Alam-Faruque, Yasmin
Sawford, Tony
O'Donovan, Claire
Martin, Maria J.
Bely, Benoit
Browne, Paul
Chan, Wei Mun
Eberhardt, Ruth
Gardner, Michael
Laiho, Kati
Legge, Duncan
Magrane, Michele
Pichler, Klemens
Poggioli, Diego
Sehra, Harminder
Auchincloss, Andrea
Axelsen, Kristian
Blatter, Marie-Claude
Boutet, Emmanuel
Braconi-Quintaje, Silvia
Breuza, Lionel
Bridge, Alan
Coudert, Elizabeth
Estreicher, Anne
Famiglietti, Livia
Ferro-Rojas, Serenella
Feuermann, Marc
Gos, Arnaud
Gruaz-Gumowski, Nadine
Hinz, Ursula
Hulo, Chantal
James, Janet
Jimenez, Silvia
Jungo, Florence
Keller, Guillaume
Lemercier, Phillippe
Lieberherr, Damien
Masson, Patrick
Moinat, Madelaine
Pedruzzi, Ivo
Poux, Sylvain
Rivoire, Catherine
Roechert, Bernd
Schneider, Michael
Stutz, Andre
Sundaram, Shyamala
Tognolli, Michael
Bougueleret, Lydie
[J]. NUCLEIC ACIDS RESEARCH, 2012, 40 (D1) : D565 - D570
[4] CLONING AND CHARACTERIZATION OF A NATURALLY-OCCURRING ANTISENSE RNA TO HUMAN THYMIDYLATE SYNTHASE MESSENGER-RNA
DOLNICK, BJ
[J]. NUCLEIC ACIDS RESEARCH, 1993, 21 (08) : 1747 - 1752
[5] Its gene expression is associated with altered cell sensitivity to thymidylate synthase inhibitors
Dolnick, BJ
Black, AR
Winkler, PM
Schindler, K
Hsueh, CT
[J]. ADVANCES IN ENZYME REGULATION, VOL 36, 1996, 36 : 165 - 180
[6] The ChEBI reference database and ontology for biologically relevant chemistry: enhancements for 2013
Hastings, Janna
de Matos, Paula
Dekker, Adriano
Ennis, Marcus
Harsha, Bhavana
Kale, Namrata
Muthukrishnan, Venkatesh
Owen, Gareth
Turner, Steve
Williams, Mark
Steinbeck, Christoph
[J]. NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) : D456 - D463
[7] InterPro in 2011: new developments in the family and domain prediction database
Hunter, Sarah
Jones, Philip
Mitchell, Alex
Apweiler, Rolf
Attwood, Teresa K.
Bateman, Alex
Bernard, Thomas
Binns, David
Bork, Peer
Burge, Sarah
de Castro, Edouard
Coggill, Penny
Corbett, Matthew
Das, Ujjwal
Daugherty, Louise
Duquenne, Lauranne
Finn, Robert D.
Fraser, Matthew
Gough, Julian
Haft, Daniel
Hulo, Nicolas
Kahn, Daniel
Kelly, Elizabeth
Letunic, Ivica
Lonsdale, David
Lopez, Rodrigo
Madera, Martin
Maslen, John
McAnulla, Craig
McDowall, Jennifer
McMenamin, Conor
Mi, Huaiyu
Mutowo-Muellenet, Prudence
Mulder, Nicola
Natale, Darren
Orengo, Christine
Pesseat, Sebastien
Punta, Marco
Quinn, Antony F.
Rivoire, Catherine
Sangrador-Vegas, Amaia
Selengut, Jeremy D.
Sigrist, Christian J. A.
Scheremetjew, Maxim
Tate, John
Thimmajanarthanan, Manjulapramila
Thomas, Paul D.
Wu, Cathy H.
Yeats, Corin
Yong, Siew-Yit
[J]. NUCLEIC ACIDS RESEARCH, 2012, 40 (D1) : D306 - D312
[8] UniProt archive
Leinonen, R
Diez, FG
Binns, D
Fleischmann, W
Lopez, R
Apweiler, R
[J]. BIOINFORMATICS, 2004, 20 (17) : 3236 - 3237
[9] A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway
Lu, Min
Zak, Jaroslav
Chen, Shuo
Sanchez-Pulido, Luis
Severson, David T.
Endicott, Jane
Ponting, Chris P.
Schofield, Christopher J.
Lu, Xin
[J]. CELL, 2014, 157 (05) : 1130 - 1145
[10] The International Nucleotide Sequence Database Collaboration
Nakamura, Yasukazu
Cochrane, Guy
Karsch-Mizrachi, Ilene
[J]. NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) : D21 - D24

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