Topical anti-inflammatory activity of Salvia officinalis L. leaves:: the relevance of ursolic acid

被引:313
作者
Baricevic, D [1 ]
Sosa, S
Della Loggia, R
Tubaro, A
Simonovska, B
Krasna, A
Zupancic, A
机构
[1] Univ Ljubljana, Biotech Fac, Dept Agron, Ljubljana 1111, Slovenia
[2] Univ Trieste, DEMREP, I-34100 Trieste, Italy
[3] Natl Inst Chem Ljubljana, Ljubljana 1111, Slovenia
关键词
Salvia officinalis; Lamiaceae; anti-inflammatory activity; plant extracts; ursolic acid;
D O I
10.1016/S0378-8741(00)00396-2
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Salvia officinalis L. leaves, obtained from four plant populations of different origin, were investigated for their topical anti-inflammatory properties. The n-hexane and the chloroform extracts dose-dependently inhibited the Croton oil-induced ear oedema in mice, the chloroform extracts being the most active. By contrast, the methanol extracts showed a very low effect and the essential oil was inactive. Chemical and pharmacological investigation of the most potent chloroform extract, issued from an autochthonous sage population grown in the submediterranean climatic region of Slovenia, revealed ursolic acid as the main component involved in its anti-inflammatory activity. The anti-inflammatory effect of ursolic acid (ID50 = 0.14 mu Moles/cm(2)) was two fold more potent than that of indomethacin (ID50=0.26 mu Moles/cm(2)), which was used as a reference non-steroidal anti-inflammatory drug (NSAID). The content of ursolic acid in sage and sage-based remedies for the topical treatment of inflammatory diseases is proposed as a parameter for quality control purposes. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:125 / 132
页数:8
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