Analysis and optimization of biochemical process reaction pathways. 1. Pathway sensitivities and identification of limiting steps

被引：8

作者：

Conejeros, R ^{[1
]}

Vassiliadis, VS ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem Engn, Cambridge CB2 3RA, England

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 1998年 / 37卷 / 12期

关键词：

D O I：

10.1021/ie980410k

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This work focuses on establishing a link between biochemical reactions and the macroscopic fermentation process by using a set of amplification/attenuation factors which influence individually each reaction step. A sensitivity analysis based on these factors yields a novel measure of reaction step influence on the overall process objective. These measures are generalized to any type of processing mode, primarily focusing on dynamic processes, for which it is shown how the sensitivities can be used to identify reaction network bottlenecks.

引用

页码：4699 / 4708

页数：10

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