The molecular basis for public T-cell responses?

被引：265

作者：

Venturi, Vanessa ^{[3
]}

Price, David A. ^{[1
,2
]}

Douek, Daniel C. ^{[1
]}

Davenport, Miles P. ^{[3
]}

机构：

[1] NIAID, NIH, Vaccine Res Ctr, Human Immunol Sect, Bethesda, MD 20892 USA

[2] Cardiff Univ, Sch Med, Dept Med Biochem & Immunol, Cardiff CF14 4XN, Wales

[3] Univ New S Wales, Ctr Vasc Res, Complex Syst Biol Grp, Sydney, NSW 2052, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nri2260

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Public T-cell responses, in which T cells bearing identical T-cell receptors (TCRs) are observed to dominate the response to the same antigenic epitope in multiple individuals, have long been a focus of immune T-cell repertoire studies. However, the mechanism that enables the survival of a specific TCR from the diverse repertoire produced in the thymus through to its involvement in a public immune response remains unclear. In this Opinion article, we propose that the frequency of production of T cells bearing different TCRs during recombination has an important role in the sharing of TCRs in an immune response, with variable levels of 'convergent recombination' driving production frequencies.

引用

页码：231 / U14

页数：8