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CB1-cannabinoid and μ-opioid receptor co-localization on postsynaptic target in the rat dorsal horn

被引：134
作者：
Salio, C
Fischer, J
Franzoni, MF
Mackie, K
Kaneko, T
Conrath, M
机构：
[1] Univ Paris 06, CNRS, UMR 7624, F-75252 Paris, France
[2] Dipartimento Biol Anim & Uomo, I-10123 Turin, Italy
[3] Univ Washington, Dept Anesthesiol, Seattle, WA 98195 USA
[4] Kyoto Univ, Grad Sch Med, Dept Morphol Brain Sci, Kyoto 6068501, Japan
来源：
NEUROREPORT | 2001年 / 12卷 / 17期
关键词：
immunocytochemistry; pain; spinal interneuron; ultrastructure;
D O I：
10.1097/00001756-200112040-00017
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cannabinoids and opioids interact in the control of nociception at the spinal level. Likely, several mechanisms are involved, with one of them being co-localization of cannabinoid and opioid receptors. In order to validate this hypothesis, a double labeling study of CBI cannabinoid receptors and mu -opioid receptors in the dorsal horn of the rat spinal cord was performed. A strong co-localization of CBI I and L-opioid receptors was observed in lamina II interneurons at the ultrastructural level. The physiological consequences of the co-localization are discussed. NeuroReport 12:3689-3692 (C) 2001 Lippincott Williams & Wilkins.
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页码：3689 / 3692
页数：4
相关论文
共 26 条
[1]   Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR-1C within the human spinal cord [J].
Abbadie, C ;
Gultekin, SH ;
Pasternak, GW .
NEUROREPORT, 2000, 11 (09) :1953-1957
[2]  
Aicher SA, 2000, SYNAPSE, V36, P12, DOI 10.1002/(SICI)1098-2396(200004)36:1<12::AID-SYN2>3.0.CO
[3]  
2-E
[4]  
Cichewicz DL, 1999, J PHARMACOL EXP THER, V289, P859
[5]   Delta-9-tetrahydrocannabinol increases prodynorphin and proenkephalin gene expression in the spinal cord of the rat [J].
Corchero, J ;
Avila, MA ;
Fuentes, JA ;
Manzanares, J .
LIFE SCIENCES, 1997, 61 (04) :PL39-PL43
[6]   EFFECT OF CHRONIC PRENATAL MORPHINE TREATMENT ON MU-OPIOID RECEPTOR-REGULATED ADENYLATE-CYCLASE ACTIVITY AND NEUROTRANSMITTER RELEASE IN RAT-BRAIN SLICES [J].
DEVRIES, TJ ;
VANVLIET, BJ ;
HOGENBOOM, F ;
WARDEH, G ;
VANDERLAAN, JW ;
MULDER, AH ;
SCHOFFELMEER, ANM .
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1991, 208 (02) :97-104
[7]  
Ding YQ, 1996, J COMP NEUROL, V367, P375
[8]   Cannabinoid CB1 receptor expression in rat spinal cord [J].
Farquhar-Smith, WP ;
Egertová, M ;
Bradbury, EJ ;
McMahon, SB ;
Rice, ASC ;
Elphick, MR .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 15 (06) :510-521
[9]   GABAergic synapses on mu-opioid receptor-expressing neurons in the superficial dorsal horn: An electron microscope study in the cat spinal cord [J].
Gong, LW ;
Ding, YQ ;
Wang, D ;
Zheng, HX ;
Qin, BZ ;
Li, JS ;
Kaneko, T ;
Mizuno, N .
NEUROSCIENCE LETTERS, 1997, 227 (01) :33-36
[10]   Regulation of cannabinoid and mu opioid receptors in rat lumbar spinal cord following neonatal capsaicin treatment [J].
Hohmann, AG ;
Herkenham, M .
NEUROSCIENCE LETTERS, 1998, 252 (01) :13-16
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