CB1-cannabinoid and μ-opioid receptor co-localization on postsynaptic target in the rat dorsal horn

被引：134

作者：

Salio, C

Fischer, J

Franzoni, MF

Mackie, K

Kaneko, T

Conrath, M

机构：

[1] Univ Paris 06, CNRS, UMR 7624, F-75252 Paris, France

[2] Dipartimento Biol Anim & Uomo, I-10123 Turin, Italy

[3] Univ Washington, Dept Anesthesiol, Seattle, WA 98195 USA

[4] Kyoto Univ, Grad Sch Med, Dept Morphol Brain Sci, Kyoto 6068501, Japan

来源：

NEUROREPORT | 2001年 / 12卷 / 17期

关键词：

immunocytochemistry; pain; spinal interneuron; ultrastructure;

D O I：

10.1097/00001756-200112040-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cannabinoids and opioids interact in the control of nociception at the spinal level. Likely, several mechanisms are involved, with one of them being co-localization of cannabinoid and opioid receptors. In order to validate this hypothesis, a double labeling study of CBI cannabinoid receptors and mu -opioid receptors in the dorsal horn of the rat spinal cord was performed. A strong co-localization of CBI I and L-opioid receptors was observed in lamina II interneurons at the ultrastructural level. The physiological consequences of the co-localization are discussed. NeuroReport 12:3689-3692 (C) 2001 Lippincott Williams & Wilkins.

引用

收藏

页码：3689 / 3692

页数：4

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