Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors

被引:123
作者
Boeuf, Stephane [1 ]
Richter, Wiltrud [1 ]
机构
[1] Orthopaed Univ Hosp Heidelberg, Res Ctr Expt Orthopaed, D-69118 Heidelberg, Germany
关键词
HUMAN-BONE-MARROW; IN-VITRO CHONDROGENESIS; UMBILICAL-CORD BLOOD; HUMAN ADIPOSE-TISSUE; MULTI-LINEAGE CELLS; STROMAL CELLS; PROGENITOR CELLS; ARTICULAR CHONDROCYTES; GENE-EXPRESSION; DIFFERENTIAL EXPRESSION;
D O I
10.1186/scrt31
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Multipotent mesenchymal stromal cells (MSCs) are an attractive cell source for cell therapy in cartilage. Although their therapeutic potential is clear, the requirements and conditions for effective induction of chondrogenesis in MSCs and for the production of a stable cartilaginous tissue by these cells are far from being understood. Different sources of MSCs have been considered for cartilage tissue engineering, mainly based on criteria of availability, as for adipose tissue, or of proximity to cartilage and the joint environment in vivo, as for bone marrow and synovial tissues. Focussing on human MSCs, this review will provide an overview of studies featuring comparative analysis of the chondrogenic differentiation of MSCs from different sources. In particular, it will examine the influence of the cells' origin on the requirements for the induction of chondrogenesis and on the phenotype achieved by the cells after differentiation.
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页数:9
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共 114 条
[111]   Potential involvement of BMP receptor type IB activation in a synergistic effect of chondrogenic promotion between rhTGFβ3 and rhGDF5 or rhBMP7 in human mesenchymal stem cells [J].
Xu, Danlin ;
Gechtman, Ze'ev ;
Hughes, Anna ;
Collins, Alexander ;
Dodds, Robert ;
Cui, Xiaoling ;
Jolliffe, Linda ;
Higgins, Linda ;
Murphy, Alison ;
Farrell, Francis .
GROWTH FACTORS, 2006, 24 (04) :268-278
[112]   Stromal Vascular Progenitors in Adult Human Adipose Tissue [J].
Zimmerlin, Ludovic ;
Donnenberg, Vera S. ;
Pfeifer, Melanie E. ;
Meyer, E. Michael ;
Peault, Bruno ;
Rubin, J. Peter ;
Donnenberg, Albert D. .
CYTOMETRY PART A, 2010, 77A (01) :22-30
[113]   Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter [J].
Zimmermann, Peter ;
Boeuf, Stephane ;
Dickhut, Andrea ;
Boehmer, Sandra ;
Olek, Sven ;
Richter, Wiltrud .
ARTHRITIS AND RHEUMATISM, 2008, 58 (09) :2743-2753
[114]   Human adipose tissue is a source of multipotent stem cells [J].
Zuk, PA ;
Zhu, M ;
Ashjian, P ;
De Ugarte, DA ;
Huang, JI ;
Mizuno, H ;
Alfonso, ZC ;
Fraser, JK ;
Benhaim, P ;
Hedrick, MH .
MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (12) :4279-4295