Transdifferentiation and metaplasia - switching cell types

被引：150

作者：

Slack, JMW ^{[1
]}

Tosh, D ^{[1
]}

机构：

[1] Univ Bath, Dev Biol Programme, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-437X(00)00236-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

States of developmental commitment are encoded as combinations of transcription factors and changes in their expression can bring about transdifferentiation or metaplasia. For example, ectopic expressions of Vestigial can convert Drosophila leg to wing; of C/EBP beta can convert pancreatic exocrine cells to hepatocytes; and expression of C/EBP alpha and PPAR gamma can convert myoblasts to adipocytes.

引用

页码：581 / 586

页数：6

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