The total synthesis of (-)-tetrahydrolipstatin

被引：25

作者：

Bodkin, JA ^{[1
]}

Humphries, EJ ^{[1
]}

McLeod, MD ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Camperdown, NSW 2006, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2003年 / 56卷 / 08期

关键词：

D O I：

10.1071/CH03121

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Careful control during the bromolactonization of beta,gamma-unsaturated acid (4) was required to regioselectively afford the trans-beta-lactone (3) as the major diastereomer. Radical debromination of (3) followed by a three-step sequence of reactions afforded the lipase inhibitor (-)- tetrahydrolipstatin ( 1).

引用

页码：795 / 803

页数：9

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