Vitamin D3-dependent pathway regulates TACO gene transcription

被引：37

作者：

Anand, PK ^{[1
]}

Kaul, D ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Expt Med & Bioytechnol, Chandigarh 160012, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 310卷 / 03期

关键词：

TACO gene; transcriptiom; vitamins; macrophages; tuberculosis;

D O I：

10.1016/j.bbrc.2003.09.087

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, gene coding for tryptophan-aspartate containing coat protein (TACO) has been recognized to play a crucial role in the survival of Mycobacterium tuberculosis within human macrophages. Since regulation of TACO gene is still poorly understood, the present study was addressed to explore the role of vitamins (A, C, D, and E) in TACO gene transcription. Such a study revealed that synergistic action of vitamin D-3 and retinoic acid (RA) had inherent ability to down-regulate TACO gene transcription in human macrophages. Based upon these results, we propose that synergistic action of RA + vitamin D may be of importance in the prevention/control of M. tuberculosis infection. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：876 / 877

页数：2

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