Distinctive Clinical and Histological Features of Waldenstrom's Macroglobulinemia and Splenic Marginal Zone Lymphoma

被引：22

作者：

Arcaini, Luca ^{[1
]}

Varettoni, Marzia ^{[1
]}

Boveri, Emanuela ^{[2
]}

Orlandi, Ester ^{[1
]}

Rattotti, Sara ^{[1
]}

Zibellini, Silvia ^{[1
]}

Merli, Michele ^{[1
]}

Lucioni, Marco ^{[2
]}

Rizzi, Silvia ^{[1
]}

Gotti, Manuel ^{[1
]}

Morello, Lucia ^{[1
]}

Pascutto, Cristiana ^{[1
]}

Paulli, Marco ^{[2
]}

机构：

[1] Univ Pavia, Sch Med, Fdn IRCCS Policlin San Matteo, Div Hematol,Dept Oncohematol, I-27100 Pavia, Italy

[2] Univ Pavia, Sch Med, Fdn IRCCS Policlin San Matteo, Dept Pathol, I-27100 Pavia, Italy

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2011年 / 11卷 / 01期

关键词：

HEPATITIS-C; MANAGEMENT; DIAGNOSIS;

D O I：

10.3816/CLML.2011.n.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We studied 122 patients with Waldenstrom's macroglobulinemia (WM) and 98 with splenic marginal zone lymphoma (SMZL); 29 SMZL patients (30%) had a serum MC (IgM in 17 patients). SMZL differed from WM for female prevalence, abdominal and superficial adenopathy, spleen and liver involvement, positive HCV. The median MC level was 2.0 g/dL in WM and 0.95 g/dL in SMZL (P < .001). On BM histology, SMZL was characterized by sinusoidal infiltration (70% of cases) and by a more frequent nodular pattern (P < .01) while WM had a higher incidence of interstitial BM localization. After a median follow-up of 5.3 years, median OS was not reached for SMZL and was 12 years for WM (P = .23; 14 years for asymptomatic WM, 8 years for symptomatic WM). In conclusion, despite similar outcomes of these 2 entities, SMZL appears as a disease with distinct clinical features and BM histology and a peculiar association with HCV infection.

引用

页码：103 / 105

页数：3

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