Conformational diversity and protein evolution - a 60-year-old hypothesis revisited

被引：471

作者：

James, LC

Tawfik, DS ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

[2] Ctr Prot Engn, Cambridge CB2 2HQ, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 07期

基金：

以色列科学基金会; 英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(03)00135-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complex organisms have evolved from a limited number of primordial genes and proteins. However, the mechanisms by which the earliest proteins evolved and then served as the origin for the present diversity of protein function are unknown. Here, we outline a hypothesis based on the 'new view' of proteins whereby one sequence can adopt multiple structures and functions. We suggest that such conformational diversity could increase the functional diversity of a limited repertoire of sequences and, thereby, facilitate the evolution of new proteins and functions from old ones.

引用

页码：361 / 368

页数：8

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2-O

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[Anonymous], 1936, SPECIFICITY SEROLOGI

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