The search for the ideal biocatalyst

被引：232

作者：

Burton, SG

Cowan, DA

Woodley, JM

机构：

[1] Univ Cape Town, Dept Chem Engn, ZA-7925 Cape Town, South Africa

[2] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

[3] UCL, Dept Biochem Engn, London WC1E 7JE, England

来源：

NATURE BIOTECHNOLOGY | 2002年 / 20卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 新加坡国家研究基金会;

关键词：

D O I：

10.1038/nbt0102-37

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

While the use of enzymes as biocatalysts to assist in the industrial manufacture of fine chemicals and pharmaceuticals has enormous potential, application is frequently limited by evolution-led catalyst traits. The advent of designer biocatalysts, produced by informed selection and mutation through recombinant DNA technology, enables production of process-compatible enzymes. However, to fully realize the potential of designer enzymes in industrial applications, it will be necessary to tailor catalyst properties so that they are optimal not only for a given reaction but also in the context of the industrial process in which the enzyme is applied.

引用

页码：37 / 45

页数：9

共 83 条

[1] ON THE IMPORTANCE OF THE SUPPORT MATERIAL FOR ENZYMATIC-SYNTHESIS IN ORGANIC MEDIA - SUPPORT EFFECTS AT CONTROLLED WATER ACTIVITY [J].