Neurotoxicity following addition of intravenous valproate to lamotrigine therapy

被引：5

作者：

Burneo, JG

Kuzniecky, RI

Knowlton, RC

Mendez, M

Lawn, N

Faught, E

Welty, TE

Prasad, A

机构：

[1] Univ Alabama, Dept Neurol, Epilepsy Div, Sch Med, Birmingham, AL 35294 USA

[2] Samford Univ, Dept Neurol, McWhorter Sch Pharm, Birmingham, AL 35229 USA

[3] Samford Univ, Dept Pharm, McWhorter Sch Pharm, Birmingham, AL 35229 USA

来源：

NEUROLOGY | 2003年 / 60卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000065915.68602.91

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Reversible neurotoxic symptoms were observed in three adult patients with absence status epilepticus on lamotrigine (LTG) therapy after administration of an IV bolus followed by oral valproic acid (VPA). Neurotoxicity was likely related to elevated serum LTG levels, as improvement correlated with discontinuing or reducing LTG dosage.

引用

页码：1991 / 1992

页数：2

共 8 条

[1]

Decerce John, 2000, Epilepsia, V41, P220

[2]

Genton P., 2002, ANTIEPILEPTIC DRUGS, P837

[3] Adding valproate to lamotrigine: A study of their pharmacokinetic interaction [J].